Across Latin America and the Caribbean (LAC), investors, health system leaders, accelerators, governments, and multinational corporations are looking to identify and evaluate novel approaches to affordable, quality healthcare. Since the launch of our network in 2011, Innovations in Healthcare has worked with many forward-thinking healthcare organizations in LAC, including MedicallHome, APROFE, and salauno. Our efforts have identified clusters of innovations emerging in Mexico, Brazil, and Central America. We noted the growing interest from multiple stakeholders, and, in response, decided to study and analyze those clusters to better understand trends in the region, along with specific ecosystem characteristics that promote or hinder the development and scale of healthcare innovation. The resulting landscape study we present here focuses on Brazil, Colombia, and Mexico.